Investors & Media
Phase 1 Clinical Data With Cyclacel’s CYC065 CDK Inhibitor Have Been Selected for Oral Presentation at AACR 2018 Annual Meeting
Clinical data from part 1 of an ongoing, first-in-human, Phase 1, dose escalation study of CYC065 has been selected for oral presentation. Details are as follows:
|Title:||Phase I safety, pharmacokinetic and pharmacodynamic study of CYC065, a cyclin dependent kinase inhibitor, in patients with advanced cancers (NCT02552953)|
|Category:||Phase I Adult Clinical Trials|
|Session:||CTMS01 - New Treatment Approaches for Breast and Ovarian Cancer|
|Location:||Room N427 - McCormick Place North (Level 4)|
|Date and Time:||Sunday, April 15, 2018, 3:00 PM - 5:00 PM|
The abstract is embargoed at this time and will be made available in accordance with AACR rules at http://www.abstractsonline.com/pp8/#!/4562/presentation/11142.
Preclinical data by academic collaborators of the Company evaluating the rationale for potential combination regimens of CYC065 and venetoclax, a Bcl-2 inhibitor approved for patients with certain chronic lymphocytic leukemias (CLL) under conditions that mimic the lymph node tumor microenvironment, have been selected for a poster presentation. Details are as follows:
|Title:||Strategic combination of the cyclin-dependent kinase inhibitor CYC065 with venetoclax to target anti-apoptotic proteins in chronic lymphocytic leukemia|
|Category:||Experimental and Molecular Therapeutics|
|Session:||PO.ET07.03 - Receptor Targeting and the Tumor Microenvironment|
|Abstract #:||3905/ 5|
|Location:||McCormick Place South, Exhibit Hall A, Poster Section 38|
|Date and Time:||Tuesday, April 17, 2018, 8:00 AM - 12:00 PM|
The abstract is available at www.abstractsonline.com/pp8/#!/4562/presentation/4821.
CYC065, a second generation CDK2/9 inhibitor, is being evaluated in a first-in-human, Phase 1 trial in patients with advanced solid tumors. It is mechanistically similar but has higher dose potency, in vitro and in vivo, and improved properties compared to seliciclib, a first generation CDK inhibitor. Similarly to
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|Company:||Paul McBarron, (908) 517-7330, firstname.lastname@example.org|
|Investor Relations:||Russo Partners LLC, Alexander Fudukidis, (646) 942-5632,|
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