United States
                       Securities and Exchange Commission
                             WASHINGTON, D.C. 20549


                                  Schedule 13G
                               (Amendment No. __)*

                    UNDER THE SECURITIES EXCHANGE ACT OF 1934


                              XCYTE THERAPIES, INC.
             ------------------------------------------------------
                                (Name of Issuer)

                                  Common Stock
             ------------------------------------------------------
                         (Title of Class of Securities)

                                    98389F309
             ------------------------------------------------------
                                 (CUSIP Number)


                                December 31, 2004
             ------------------------------------------------------
             (Date of Event That Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

         |_|      Rule 13d-1(b)

         |X|      Rule 13d-1(c)

         |_|      Rule 13d-1(d)

* The remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for any  subsequent  amendment  containing  information  which  would  alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).



CUSIP No. 98389F309 Page 2 of 14 Pages ------------------------------------------------------------------------------------------------------------------- (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Alta Partners ------------------------------------------------------------------------------------------------------------------- (2) Check The Appropriate Box If A Member Of A Group (a) (b) X ------------------------------------------------------------------------------------------------------------------- (3) SEC Use Only ------------------------------------------------------------------------------------------------------------------- (4) Citizenship or Place of Organization California ------------------------------------------------------------------------------------------------------------------- Please see Attachment A and Footnote 1 Number Of Shares (5) Sole Voting Power -0- Beneficially Owned By Each Reporting -------------------------------------------------------------- Person With (6) Shared Voting Power 1,567,929 Please see Attachment A and Footnote 1 -------------------------------------------------------------- (7) Sole Dispositive Power -0- -------------------------------------------------------------- (8) Shared Dispositive Power 1,567,929 Please see Attachment A and Footnote 1 ------------------------------------------------------------------------------------------------------------------- (9) Aggregate Amount Beneficially Owned By Each Reporting Person 1,567,929 Please see Attachment A and Footnote 1 ------------------------------------------------------------------------------------------------------------------- (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* ------------------------------------------------------------------------------------------------------------------- (11) Percent Of Class Represented By Amount In Row (11) 7.27% Please see Attachment A and Footnote 1 ------------------------------------------------------------------------------------------------------------------- (12) Type Of Reporting Person IA ------------------------------------------------------------------------------------------------------------------- *SEE INSTRUCTION BEFORE FILLING OUT! Footnote 1: Includes 1,117,439 shares of Common Stock and 97,766 shares of Convertible Exchangeable Preferred Stock (convertible into 416,023 shares of Common Stock) beneficially owned by Alta California Partners, L.P., and 24,961 shares of Common Stock, and 2,234 shares of Convertible Exchangeable Preferred Stock (convertible into 9,506 shares of Common Stock) beneficially owned by Alta Embarcadero Partners, LLC. Please see Attachment A.

CUSIP No. 98389F309 Page 3 of 14 Pages ------------------------------------------------------------------------------------------------------------------- (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Alta California Partners, L. P. ------------------------------------------------------------------------------------------------------------------- (2) Check The Appropriate Box If A Member Of A Group (a) (b) X ------------------------------------------------------------------------------------------------------------------- (3) SEC Use Only ------------------------------------------------------------------------------------------------------------------- (4) Citizenship or Place of Organization Delaware ------------------------------------------------------------------------------------------------------------------- Please see Attachment A and Footnote 1 Number Of Shares (5) Sole Voting Power -0- Beneficially Owned By Each Reporting -------------------------------------------------------------- Person With (6) Shared Voting Power 1,567,929 Please see Attachment A and Footnote 1 -------------------------------------------------------------- (7) Sole Dispositive Power -0- -------------------------------------------------------------- (8) Shared Dispositive Power 1,567,929 Please see Attachment A and Footnote 1 ------------------------------------------------------------------------------------------------------------------- (9) Aggregate Amount Beneficially Owned By Each Reporting Person 1,567,929 Please see Attachment A and Footnote 1 ------------------------------------------------------------------------------------------------------------------- (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* ------------------------------------------------------------------------------------------------------------------- (11) Percent Of Class Represented By Amount In Row (11) 7.27% Please see Attachment A and Footnote 1 ------------------------------------------------------------------------------------------------------------------- (12) Type Of Reporting Person PN ------------------------------------------------------------------------------------------------------------------- Footnote 1: Includes 1,117,439 shares of Common Stock and 97,766 shares of Convertible Exchangeable Preferred Stock (convertible into 416,023 shares of Common Stock) beneficially owned by Alta California Partners, L.P., and 24,961 shares of Common Stock, and 2,234 shares of Convertible Exchangeable Preferred Stock (convertible into 9,506 shares of Common Stock) beneficially owned by Alta Embarcadero Partners, LLC. Please see Attachment A.

CUSIP No. 98389F309 Page 4 of 14 Pages ------------------------------------------------------------------------------------------------------------------- (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Alta California Management Partners, L.P. ---------------------------------------------------------------------------------------------------------- (2) Check The Appropriate Box If A Member Of A Group (a) (b) X ------------------------------------------------------------------------------------------------------------------- (3) SEC Use Only ------------------------------------------------------------------------------------------------------------------- (4) Citizenship or Place of Organization Delaware ------------------------------------------------------------------------------------------------------------------- Please see Attachment A and Footnote 1 Number Of Shares (5) Sole Voting Power -0- Beneficially Owned By Each Reporting -------------------------------------------------------------- Person With (6) Shared Voting Power 1,567,929 Please see Attachment A and Footnote 1 -------------------------------------------------------------- (7) Sole Dispositive Power -0- -------------------------------------------------------------- (8) Shared Dispositive Power 1,567,929 Please see Attachment A and Footnote 1 ------------------------------------------------------------------------------------------------------------------- (9) Aggregate Amount Beneficially Owned By Each Reporting Person 1,567,929 Please see Attachment A and Footnote 1 ------------------------------------------------------------------------------------------------------------------- (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* ------------------------------------------------------------------------------------------------------------------- (11) Percent Of Class Represented By Amount In Row (11) 7.27% Please see Attachment A and Footnote 1 ------------------------------------------------------------------------------------------------------------------- (12) Type Of Reporting Person PN ------------------------------------------------------------------------------------------------------------------- Footnote 1: Includes 1,117,439 shares of Common Stock and 97,766 shares of Convertible Exchangeable Preferred Stock (convertible into 416,023 shares of Common Stock) beneficially owned by Alta California Partners, L.P., and 24,961 shares of Common Stock, and 2,234 shares of Convertible Exchangeable Preferred Stock (convertible into 9,506 shares of Common Stock) beneficially owned by Alta Embarcadero Partners, LLC. Please see Attachment A.

CUSIP No. 98389F309 Page 5 of 14 Pages ------------------------------------------------------------------------------------------------------------------- (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Alta Embarcadero Partners, LLC ------------------------------------------------------------------------------------------------------------------- (2) Check The Appropriate Box If A Member Of A Group (a) (b) X ------------------------------------------------------------------------------------------------------------------- (3) SEC Use Only ------------------------------------------------------------------------------------------------------------------- (4) Citizenship or Place of Organization California ------------------------------------------------------------------------------------------------------------------- Please see Attachment A and Footnote 1 Number Of Shares (5) Sole Voting Power -0- Beneficially Owned By Each Reporting -------------------------------------------------------------- Person With (6) Shared Voting Power 1,567,929 Please see Attachment A and Footnote 1 -------------------------------------------------------------- (7) Sole Dispositive Power -0- -------------------------------------------------------------- (8) Shared Dispositive Power 1,567,929 Please see Attachment A and Footnote 1 ------------------------------------------------------------------------------------------------------------------- (9) Aggregate Amount Beneficially Owned By Each Reporting Person 1,567,929 Please see Attachment A and Footnote 1 ------------------------------------------------------------------------------------------------------------------- (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* ------------------------------------------------------------------------------------------------------------------- (11) Percent Of Class Represented By Amount In Row (11) 7.27% Please see Attachment A and Footnote 1 ------------------------------------------------------------------------------------------------------------------- (12) Type Of Reporting Person CO ------------------------------------------------------------------------------------------------------------------- Footnote 1: Includes 1,117,439 shares of Common Stock and 97,766 shares of Convertible Exchangeable Preferred Stock (convertible into 416,023 shares of Common Stock) beneficially owned by Alta California Partners, L.P., and 24,961 shares of Common Stock, and 2,234 shares of Convertible Exchangeable Preferred Stock (convertible into 9,506 shares of Common Stock) beneficially owned by Alta Embarcadero Partners, LLC. Please see Attachment A. CUSIP No. 98389F309 Page 6 of 14 Pages ------------------------------------------------------------------------------------------------------------------- (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Jean Deleage ------------------------------------------------------------------------------------------------------------------- (2) Check The Appropriate Box If A Member Of A Group (a) (b) X ------------------------------------------------------------------------------------------------------------------- (3) SEC Use Only ------------------------------------------------------------------------------------------------------------------- (4) Citizenship or Place of Organization United States ------------------------------------------------------------------------------------------------------------------- Please see Attachment A and Footnote 1 Number Of Shares (5) Sole Voting Power 5,454 Beneficially Owned By Each Reporting -------------------------------------------------------------- Person With (6) Shared Voting Power 1,567,929 Please see Attachment A and Footnote 2 -------------------------------------------------------------- (7) Sole Dispositive Power 5,454 -------------------------------------------------------------- (8) Shared Dispositive Power 1,567,929 Please see Attachment A and Footnote 2 ------------------------------------------------------------------------------------------------------------------- (9) Aggregate Amount Beneficially Owned By Each Reporting Person 1,573,383 Please see Attachment A and Footnote 2 ------------------------------------------------------------------------------------------------------------------- (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* ------------------------------------------------------------------------------------------------------------------- (11) Percent Of Class Represented By Amount In Row (11) 7.29% Please see Attachment A and Footnote 2 ------------------------------------------------------------------------------------------------------------------- (12) Type Of Reporting Person IN ------------------------------------------------------------------------------------------------------------------- *SEE INSTRUCTION BEFORE FILLING OUT! Footnote 2: Includes 1,117,439 shares of Common Stock and 97,766 shares of Convertible Exchangeable Preferred Stock (convertible into 416,023 shares of Common Stock) beneficially owned by Alta California Partners, L.P., and 24,961 shares of Common Stock, and 2,234 shares of Convertible Exchangeable Preferred Stock (convertible into 9,506 shares of Common Stock) beneficially owned by Alta Embarcadero Partners, LLC. Mr. Deleage holds Stock Options for 5,454 shares of Common Stock. Please see Attachment A.

CUSIP No. 98389F309 Page 7 of 14 Pages ------------------------------------------------------------------------------------------------------------------- (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Garrett Gruener ------------------------------------------------------------------------------------------------------------------- (2) Check The Appropriate Box If A Member Of A Group (a) (b) X ------------------------------------------------------------------------------------------------------------------- (3) SEC Use Only ------------------------------------------------------------------------------------------------------------------- (4) Citizenship or Place of Organization United States ------------------------------------------------------------------------------------------------------------------- Please see Attachment A and Footnote 1 Number Of Shares (5) Sole Voting Power -0- Beneficially Owned By Each Reporting -------------------------------------------------------------- Person With (6) Shared Voting Power 1,567,929 Please see Attachment A and Footnote 1 -------------------------------------------------------------- (7) Sole Dispositive Power -0- -------------------------------------------------------------- (8) Shared Dispositive Power 1,567,929 Please see Attachment A and Footnote 1 ------------------------------------------------------------------------------------------------------------------- (9) Aggregate Amount Beneficially Owned By Each Reporting Person 1,567,929 Please see Attachment A and Footnote 1 ------------------------------------------------------------------------------------------------------------------- (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* ------------------------------------------------------------------------------------------------------------------- (11) Percent Of Class Represented By Amount In Row (11) 7.27% Please see Attachment A and Footnote 1 ------------------------------------------------------------------------------------------------------------------- (12) Type Of Reporting Person IN ------------------------------------------------------------------------------------------------------------------- *SEE INSTRUCTION BEFORE FILLING OUT! Footnote 1 Includes 1,117,439 shares of Common Stock and 97,766 shares of Convertible Exchangeable Preferred Stock (convertible into 416,023 shares of Common Stock) beneficially owned by Alta California Partners, L.P., and 24,961 shares of Common Stock, and 2,234 shares of Convertible Exchangeable Preferred Stock (convertible into 9,506 shares of Common Stock) beneficially owned by Alta Embarcadero Partners, LLC. Please see Attachment A.

CUSIP No. 98389F309 Page 8 of 14 Pages ------------------------------------------------------------------------------------------------------------------- (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Guy Nohra ------------------------------------------------------------------------------------------------------------------- (2) Check The Appropriate Box If A Member Of A Group (a) (b) X ------------------------------------------------------------------------------------------------------------------- (3) SEC Use Only ------------------------------------------------------------------------------------------------------------------- (4) Citizenship or Place of Organization United States ------------------------------------------------------------------------------------------------------------------- Please see Attachment A and Footnote 3 Number Of Shares (5) Sole Voting Power -0- Beneficially Owned By Each Reporting -------------------------------------------------------------- Person With (6) Shared Voting Power 1,533,462 Please see Attachment A and Footnote 3 -------------------------------------------------------------- (7) Sole Dispositive Power -0- -------------------------------------------------------------- (8) Shared Dispositive Power 1,533,462 Please see Attachment A and Footnote 3 ------------------------------------------------------------------------------------------------------------------- (9) Aggregate Amount Beneficially Owned By Each Reporting Person 1,533,462 Please see Attachment A and Footnote 3 ------------------------------------------------------------------------------------------------------------------- (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* ------------------------------------------------------------------------------------------------------------------- (11) Percent Of Class Represented By Amount In Row (11) 7.11% Please see Attachment A and Footnote 3 ------------------------------------------------------------------------------------------------------------------- (12) Type Of Reporting Person IN ------------------------------------------------------------------------------------------------------------------- *SEE INSTRUCTION BEFORE FILLING OUT! Footnote 3: Includes 1,117,439 shares of Common Stock and 97,766 shares of Convertible Exchangeable Preferred Stock (convertible into 416,023 shares of Common Stock) beneficially owned by Alta California Partners, L.P. Please see Attachment A. Item 1. (a) Name of Issuer: Xcyte Therapies, Inc. ("Issuer") (b) Address of Issuer's Principal Executive Offices: 1124 Columbia Street, Suite 130 Seattle, WA 98104 Item 2. (a) Name of Person Filing: Alta Partners ("AP") Alta California Partners, L.P. ("ACP") Alta California Management Partners, L.P. ("ACMP") Alta Embarcadero Partners, LLC ("AEP") Jean Deleage ("JD") Garrett Gruener ("GG") Guy Nohra ("GN") (b) Address of Principal Business Office: One Embarcadero Center, Suite 4050 San Francisco, CA 94111 (c) Citizenship/Place of Organization: Entities: AP California ACP Delaware ACMP Delaware AEP California Individuals: JD United States GG United States GN United States (d) Title of Class of Securities: Common Stock (e) CUSIP Number: 98389F309 Item 3. Not applicable.

Item 4 Ownership. Please see Attachment A ------- ------------------ ----------- ----------- ------------ ----------- AP ACP ACMP AEP ------- ------------------ ----------- ----------- ------------ ----------- (a) Beneficial 1,567,929 1,567,929 1,567,929 1,567,929 Ownership ------- ------------------ ----------- ----------- ------------ ----------- (b) Percentage of 7.27% 7.27% 7.27% 7.27% Class ------- ------------------ ----------- ----------- ------------ ----------- (c) Sole Voting Power -0- -0- -0- -0- ------- ------------------ ----------- ----------- ------------ ----------- Shared Voting 1,567,929 1,567,929 1,567,929 1,567,929 Power ------- ------------------ ----------- ----------- ------------ ----------- Sole Dispositive -0- -0- -0- -0- Power ------- ------------------ ----------- ----------- ------------ ----------- Shared 1,567,929 1,567,929 1,567,929 1,567,929 Dispositive Power ------- ------------------ ----------- ----------- ------------ ----------- JD GG GN ------- ------------------ ----------- ----------- ------------ ----------- (a) Beneficial 1,573,383 1,567,929 1,533,462 Ownership ------- ------------------ ----------- ----------- ------------ ----------- (b) Percentage of 7.29% 7.27% 7.11% Class ------- ------------------ ----------- ----------- ------------ ----------- (c) Sole Voting Power 5,454 -0- -0- ------- ------------------ ----------- ----------- ------------ ----------- Shared Voting 1,567,929 1,567,929 1,533,462 Power ------- ------------------ ----------- ----------- ------------ ----------- Sole Dispositive 5,454 -0- -0- Power ------- ------------------ ----------- ----------- ------------ ----------- Shared 1,567,929 1,567,929 1,533,462 Dispositive Power ------- ------------------ ----------- ----------- ------------ ----------- Item 5. Ownership of Five Percent or Less of a Class Not Applicable. Item 6. Ownership of More than Five Percent on Behalf of Another Person Not applicable.

Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company. Not applicable. Item 8. Identification and Classification of Members of the Group No reporting person is a member of a group as defined in Section 240.13d-1(b)(1)(ii)(H) of the Act. Item 9. Notice of Dissolution of Group Not applicable. Item 10. Certification By signing below we certify that, to the best of our knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect. EXHIBITS A: Joint Filing Statement

Signature After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct. Date: February 4, 2005 ALTA PARTNERS ALTA CALIFORNIA PARTNERS, L.P. By: Alta California Management Partners, L.P. By: /s/ Jean Deleage By: /s/ Jean Deleage . ----------------------------------------- ------------------------------------------------ Jean Deleage, President Jean Deleage, General Partner ALTA CALIFORNIA MANAGEMENT PARTNERS, L.P. ALTA EMBARCADERO PARTNERS, LLC By: /s/ Jean Deleage By: /s/ Jean Deleage ----------------------------------------- ------------------------------------------------ Jean Deleage, General Partner Jean Deleage, Member /s/ Jean Deleage /s/ Guy Nohra -------------------------------------------- ------------------------------------------------ Jean Deleage Guy Nohra /s/ Garrett Gruener -------------------------------------------- Garrett Gruener

EXHIBIT A AGREEMENT OF JOINT FILING Date: February 4, 2005 Signature After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct. ALTA PARTNERS ALTA CALIFORNIA PARTNERS, L.P. By: Alta California Management Partners, L.P. By: /s/ Jean Deleage By: /s/ Jean Deleage . ----------------------------------------- ------------------------------------------------ Jean Deleage, President Jean Deleage, General Partner ALTA CALIFORNIA MANAGEMENT PARTNERS, L.P. ALTA EMBARCADERO PARTNERS, LLC By: /s/ Jean Deleage By: /s/ Jean Deleage ----------------------------------------- ----------------------------------------- Jean Deleage, General Partner Jean Deleage, Member /s/ Jean Deleage /s/ Guy Nohra -------------------------------------------- ----------------------------------------- Jean Deleage Guy Nohra /s/ Garrett Gruener -------------------------------------------- Garrett Gruener

Attachment A Alta Partners provides investment advisory services to several venture capital funds including Alta California Partners, L.P. and Alta Embarcadero Partners, LLC. Alta California Partners, L.P. beneficially owns 1,117,439 shares of Common Stock and 97,766 shares of Convertible Exchangeable Preferred Stock (convertible into 416,023 shares of Common Stock). Alta Embarcadero Partners, LLC beneficially owns 24,961 shares of Common Stock and 2,234 shares of Convertible Exchangeable Preferred Stock (convertible into 9,506 shares of Common Stock). The respective general partners and members of Alta California Partners, L.P. and Alta Embarcadero Partners, LLC exercise sole voting and investment power with respect to the shares owned by such funds. Certain principals of Alta Partners are general partners of Alta California Management Partners, L.P. (which is a general partner of Alta California Partners, L.P.) and members of Alta Embarcadero Partners, LLC. As general partners and members of such entities, they may be deemed to share voting and investment powers over the shares held by such funds. The principals of Alta Partners disclaim beneficial ownership of all such shares held by the foregoing funds, except to the extent of their proportionate pecuniary interests therein. Mr. Jean Deleage, Director, is a general partner of Alta California Management Partners, L.P. (which is the general partner of Alta California Partners, L.P.) and a member of Alta Embarcadero Partners, LLC. Thus he currently shares voting and dispositive powers over the 1,117,439 shares of Common Stock and 97,766 shares of Convertible Exchangeable Preferred Stock (convertible into 416,023 shares of Common Stock) beneficially owned by Alta California Partners, L.P., and the 24,961 shares of Common Stock and 2,234 shares of Convertible Exchangeable Preferred Stock (convertible into 9,506 shares of Common Stock) beneficially owned by Alta Embarcadero Partners, LLC. He disclaims beneficial ownership of all such shares held by the foregoing funds except to the extent of his proportionate pecuniary interests therein. He holds Stock Options for 5,454 shares of Common Stock granted 11/15/1996 which were fully vested on 11/15/2001 and will expire on 11/15/2006. Mr. Garrett Gruener is a general partner of Alta California Management Partners, L.P. (which is the general partner of Alta California Partners, L.P.) and a member of Alta Embarcadero Partners, LLC. Thus he currently shares voting and dispositive powers over the 1,117,439 shares of Common Stock and 97,766 shares of Convertible Exchangeable Preferred Stock (convertible into 416,023 shares of Common Stock) beneficially owned by Alta California Partners, L.P., and the 24,961 shares of Common Stock and 2,234 shares of Convertible Exchangeable Preferred Stock (convertible into 9,506 shares of Common Stock) beneficially owned by Alta Embarcadero Partners, LLC. He disclaims beneficial ownership of all such shares held by the foregoing funds except to the extent of his proportionate pecuniary interests therein. Mr. Guy Nohra is a general partner of Alta California Management Partners, L.P. (which is the general partner of Alta California Partners, L.P.). Thus he currently shares voting and dispositive powers over the 1,117,439 shares of Common Stock and 97,766 shares of Convertible Exchangeable Preferred Stock (convertible into 416,023 shares of Common Stock) beneficially owned by Alta California Partners, L.P. He disclaims beneficial ownership of all such shares held by the foregoing funds except to the extent of his proportionate pecuniary interests therein. Alta Partners is a venture capital firm with an office in San Francisco. Alta Partners is California Corporation. Alta California Partners, L.P. is a Delaware Limited Partnership, and Alta Embarcadero Partners, LLC is a California Limited Liability Company.